Summer Research at Michigan State University

I was given the opportunity to do research in biostatistics this summer at Michigan State University. My team worked on identifying protein-protein interactions (PPI) between membrane proteins of the plant, Arabidopsis thaliana. The biologists who conducted the experiment used a mating-based Split Ubiquitin System (mbSUS) to investigate interactions between proteins by utilizing yeast as a heterologous system. We developed a mixed model to improve the modeling of yeast growth, which provides a more accurate detection of the PPI since it can be observed through the fluorescence scores. The model was applied to detect interactions between thousands of Arabidopsis membrane proteins. This summer research has been a wonderful and worthwhile experience.

~Sarah Jermeland

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